University of Wisconsin Madison
Engineering Extracellular Matrices (B M E 545) Syllabus
Course Learning Outcomes
    Course Learning Outcome
  • 1
    understanding extracellular matrix biology as related to regenerative medicine and tissue engineering
  • 2
    apply knowledge of engineering design to solve problems at the interface of extracellular matrix biology and tissue engineering
  • 3
    communicate by oral, written and graphic modes
Engineering Extracellular Matrices
B M E 545 ( 3 Credits )
Overview of the structure, function and biophysical properties of extracellular matrix (ECM) proteins, followed by discussion of how control or manipulation of ECM protein expression and distribution impacts on cell and tissue function, concluding with impacts of engineering ECM for regenerative medicine.
Zoology 151 or equiv., BME 430 or equiv. Also recommended: Zoology 570 or equiv., Bmolchem 503 or equiv
College: College of Engineering
Instructor Name
Instructor Campus Address
Contact Hours
Course Coordinator
Text book, title, author, and year
Supplemental Materials

Relevant journal articles and excerpts from the following texts are provided: Molecular Biology of the Cell (Alberts), Cell Biology of the Extracellular Matrix (Hay), and Extracellular Matrix Biology (Hynes)

Required / Elective / Selected Elective
Selected Elective
ABET Program Outcomes Associated with this Course
Program Specific Student Outcomes
(1) Understanding of biology and physiology as related to biomedical engineering needs.
(2) Ability to apply knowledge of advanced mathematics (including differential equations and statistics), sciences, and engineering to solve problems at the interface of engineering and biology and to model biological systems
Brief List of Topics to be Covered

ECM Components (Structure, Function, Biophysical Properties), ECM Functionality (Receptors, Integration of signals between integrins and growth factors, Mechanics, Remodeling), Engineering ECM-based Microenvironments (Microenvironments, Materials, Assessment, Implications Biological Science and Clinical Medicine). Literature Learning:  Opportunity to work as a group to share recent research findings related to Engineering Extracellular Matrices

Additional Information
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