Apply engineering techniques to control the stem cell microenvironment.
Apply insights from tissue development toward tissue regeneration and tissue engineering.
Stem Cell Bioengineering
B M E 520
( 3 Credits )
Covers engineering approaches that are used to understand and manipulate stem cells. Concepts covered include: introduction to stem cell biology, quantitative modeling of stem cell signaling, methods to engineer the stem cell microenvironment, and the role of stem cells in tissue development and regeneration.
Math 319 or 320, Zoology 470 or 570, Chem 343, or cons inst
Department: BIOMEDICAL ENGINEERING College: College of Engineering
Course packet with chapters and manuscripts from the contemporary Stem Cell Bioengineering literature.
Required / Elective / Selected Elective
ABET Program Outcomes Associated with this Course
Program Specific Student Outcomes
(1) Understanding of biology and physiology as related to biomedical engineering needs. (2) Ability to apply knowledge of advanced mathematics (including differential equations and statistics), sciences, and engineering to solve problems at the interface of engineering and biology and to model biological systems (3) Ability to design and conduct experiments, including making measurements and interpreting experimental data from living systems and addressing the problems associated with the interaction between living systems and non-living materials and systems
Brief List of Topics to be Covered
The interface between bioengineering and stem cell biology is among the most intriguing and active areas of inquiry in modern biotechnology. The aim of this course is to illuminate and explore this interdisciplinary research area, with an emphasis on fundamental stem cell biology, modeling of stem cell signaling, control over the stem cell microenvironment, and stem cell-based tissue development and regeneration. The course will begin by introducing important fundamental aspects of stem cell biology, followed by modules (shown below) covering bioengineering focus areas as they relates to stem cell understanding and manipulation. Each class period will include a lecture on a fundamental topic followed by a brief discussion about work that is of particular significance in the current stem cell bioengineering literature. The course is geared primarily toward graduate students with backgrounds and interests in stem cell biology and bioengineering, and students will be expected to take an active role in both lectures and discussion portions of the course.
Module 1: Fundamentals of Stem Cell Biology Module 2: Modeling of Stem Cell Signal Transduction Module 3: Engineering the Stem Cell Microenvironment – 2D-3D Module 4: Stem Cell-Based Tissue Development and Regeneration – 3D-4D Module 5: Stem Cell Policy and Ethics