University of Wisconsin Madison
Biological Interactions with Materials (B M E 430) Syllabus
Course Learning Outcomes
    Course Learning Outcome
  • 1
    understand and to integrate biology and material science and engineering
  • 2
    apply this integrated knowledge in the design of materials for a specific biomedical application
  • 3
    develop critical experimental design and data assessment of data related to biological response to materials
  • 4
    be aware of the clinical utility and limitation of materials for biomedical applications
Biological Interactions with Materials
B M E 430 ( 3 Credits )
This course addresses the range of materials currently being utilized for various biomedical applications, the biological systems governing biomaterial applications, analytical techniques pertinent to biomaterial evaluation, and selected major medical applications in which biomaterials play an important role.
1 yr of general biol or two semesters of zool, & 1 semester of organic chem, or cons inst
College: College of Engineering
Instructor Name
Instructor Campus Address
Contact Hours
Course Coordinator
Text book, title, author, and year

Biomaterials Science - An Introduction to Materials in Medicine, Ratner, Buddy D., et al. (ed.). New York: Elsevier, 2004 (2nd Ed).

Supplemental Materials

Recorded lectures and discussion sections

Required / Elective / Selected Elective
ABET Program Outcomes Associated with this Course
Program Specific Student Outcomes
(1) Understanding of biology and physiology as related to biomedical engineering needs.
(3) Ability to design and conduct experiments, including making measurements and interpreting experimental data from living systems and addressing the problems associated with the interaction between living systems and non-living materials and systems
Brief List of Topics to be Covered

Biomaterials are synthetic or biological materials used for the permanent augmentation or replacement of tissues, as well as for applications that require a relative short duration. A wide range of different materials are employed in the construction of biomedical devices such as artificial blood vessels, mechanical heart valves, breast implants, orthopedic joints, dental fillings, and devices such as intravenous catheters and drug delivery vehicles.

The lecture portion of the course covers:

  • Proteins, cells, tissues
  • Coagulation, inflammation, immunology, toxicity, infection
  • Metals, ceramics, composites
  • Polymers, hydrogels, bioresorbables
  • Natural materials, auto/allo/xeno-grafts, surface modification
  • Biological and Material characterization
  • Tissue Engineering, cardiovascular, orthopedic, drug delivery biomaterials

The hands-on laboratories complement the course material and further strengthen course outcomes and learning objectives.  Lab exercises include biomaterial fabrication, applications and characterization. 

Additional Information
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