Shuler, M. and Fikret Kargi. Bioprocess engineering: basic concepts, 2nd Edition. Prentice Hall, 2002 Glazer, AN, Hiroshi Nikaido. Microbial biotechnology: fundamentals of applied microbiology, 2nd Edition. Cambridge University Press, 2007 Blanch, H. and Clark. Biochemical Engineering. 1st Edition. Marcel Dekker, 1997 Ratledge, C. and Bjørn Kristiansen. Basic Biotechnology, 3rd Edition. Cambridge University Press, 2006. Clark, D. and Nanette Pazdernik, Academic Cell: Biotechnology.
Required / Elective / Selected Elective
ABET Program Outcomes Associated with this Course
Program Specific Student Outcomes
(1) Understanding of biology and physiology as related to biomedical engineering needs. (2) Ability to apply knowledge of advanced mathematics (including differential equations and statistics), sciences, and engineering to solve problems at the interface of engineering and biology and to model biological systems.
Brief List of Topics to be Covered
Course overview and basic cell biology, Enzymes and enzyme kinetics, Enzyme inhibition and gene expression, Regulation and metabolism, Nutrients, yield coefficients, and cell growth, Growth models and bioreactor design, Bioreactor scale-up and synthetic biology, Advanced bioreactors, Transport in biochemical engineering, Downstream processing, Metabolic engineering, Digestion, Directed Evolution and natural product biosynthesis, Case Studies